CELL2007 Molecular Exploration Project
Group 7
The overal quaternary structure of TESK1 has not yet been determined through crystallography or NMR techniques. However, by utilising various software it has been possible to predict the structure of TESK1. Predictions of the secondary/tertiary structure along with the possible domains were done using the following online servers: Phyre2, Psipred, Swiss-model and 3D Ligand Site. Further analysis was done using Kyte-doolittle to produce a hydropathy plot.
TESK1 Structural Predictions
Video: 2CPK pdb file used to create video in chimera. Classic archetype of a protein kinase domain.
[1] UCSF Chimera--a visualization system for exploratory research and analysis. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. J Comput Chem.2004 Oct;25(13):1605-12.